Analytical sciences have played a central role in the development of neuroscience, a field in which molecular measurements of neurotransmitters and other biologically relevant molecules are routinely employed to ask fundamental questions about the brain. Neuroscientist...
This is Chapter 8 in Volume 31 of the Handbook of Behavioral Neuroscience.
Serotonin's involvement in many physiological processes including anxiety, stress, aggression, and mood has been known for decades; however, a more in-depth characterization of serotonin functio...
It is important to monitor serotonin neurochemistry in the context of brain disorders. Specifically, a better understanding of biophysical alterations and associated biochemical functionality within subregions of the brain will enable better of understanding of disease...
The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and behavioral learning. Disrupt...
The medial prefrontal cortex (mPFC) is an important brain region, that controls a variety of behavioral and functional outputs. As an important step in characterizing mPFC functionality, in this paper we focus on chemically defining serotonin transmission in this area....
Between 30 and 60% of HIV-seropositive individuals develop symptoms of clinical depression and/or apathy. Dopamine and serotonin are associated with motivational alterations; however, histamine is less well studied. In the present study, we used fast-scan cyclic voltam...
It is extremely challenging to chemically diagnose disorders of the brain. There is hence great interest in designing and optimizing tools for direct detection of chemical biomarkers implicated in neurological disorders to improve diagnosis and treatment. Tools that ar...
Depression is a highly prevalent psychiatric disorder, impacting females at a rate roughly twice that of males. This disparity has become the focus of many studies which are working to determine if there are environmental or biological underpinnings to depression patho...
Fast-scan cyclic voltammetry (FSCV) is an analytical tool used to probe neurochemical processes in real-time. A major drawback for specialized applications of FSCV is that instrumentation must be constructed or modified in-house by those with expertise in electronics....
This chapter in the Encyclopedia of Analytical Science focuses on analytical detection methods for measuring neurotransmitters in vivo. The discussion begins by outlining the challenges of in vivo neurotransmitter analysis. Then, microdialysis, an in vivo sampling meth...
