hashemilab | publications

Analytical science in neurochemistry

Analytical sciences have played a central role in the development of neuroscience, a field in which molecular measurements of...

Electrochemical detection of serotonin release in rodents

This is Chapter 8 in Volume 31 of the Handbook of Behavioral Neuroscience. Serotonin's involvement in many physiological processes...

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses

It is important to monitor serotonin neurochemistry in the context of brain disorders. Specifically, a better understanding of...

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-

The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT) ensures the phasic nature of the DA signal, which...

Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the m

The medial prefrontal cortex (mPFC) is an important brain region, that controls a variety of behavioral and functional outputs. As an...

Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein ex

Between 30 and 60% of HIV-seropositive individuals develop symptoms of clinical depression and/or apathy. Dopamine and serotonin are...

Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmit

It is extremely challenging to chemically diagnose disorders of the brain. There is hence great interest in designing and optimizing...

In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escital

Depression is a highly prevalent psychiatric disorder, impacting females at a rate roughly twice that of males. This disparity has become...

A simplified LED-driven switch for fast-scan controlled-adsorption voltammetry instrumentation

Fast-scan cyclic voltammetry (FSCV) is an analytical tool used to probe neurochemical processes in real-time. A major drawback for...

Brain Chemistry | Neurotransmitters

This chapter in the Encyclopedia of Analytical Science focuses on analytical detection methods for measuring neurotransmitters in vivo....

Recent Developments in Carbon Sensors for At-Source Electroanalysis

Our understanding of the world around us has been greatly enhanced by our ability to detect and quantify analytes in the environment and...

Novel Frontiers in Voltammetric Trace Metal Analysis: Towards Real Time, On-Site, In Situ Measuremen

Metal speciation analysis has wide applicability and reveals how and when metals are available to engage in chemical processes. Real...

Analysis of Electrochemically Elusive Trace Metals with Carbon Fiber Microelectrodes

There is great interest in rapidly monitoring metals of biological and environmental interest. Electrochemistry is traditionally a...

A mathematical model for histamine synthesis, release, and control in varicosities.

Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it...

In Vivo Ambient Serotonin Measurements at Carbon-fiber Microelectrodes

The mechanisms that control extracellular serotonin levels in vivo are not well-defined. This shortcoming makes it very challenging to...

3D Carbon Nanofiber Microelectrode Array Fabricated by Plasma-assisted Pyrolysis to Enhance Sensitiv

In this paper, we have fabricated 3D carbon nanofiber microelectrode arrays (MEAs) with highly reproducible and rich chemical surface...

Fast voltammetry of metals at carbon-fiber microelectrodes: towards an online speciation sensor

Speciation controls the chemical behavior of trace metals. Thus, there is great demand for rapid speciation analysis in a variety of...

Modulation of Serotonin Dynamics in the Dorsal Raphe Nucleus via High Frequency Medial Prefontal Cor

The subcallosal cingulate (SCC) region, or its rodent homologue the medial prefrontal cortex (mPFC), and midbrain dorsal raphe (DR) are...

Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury

It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional...

Fast voltammetry of metals at carbon-fiber microelectrodes: rapid determination of solution formatio

Metal speciation controls the behavior of aqueous metal ions. Fundamental thermodynamic parameters, such as the formation constant (Kf)...

A Voltammetric and Mathematical Analysis of Histaminergic Modulation of Serotonin in the Mouse Hypot

Histamine and serotonin are neuromodulators which facilitate numerous, diverse neurological functions. Being co-localized in many brain...

A Novel, Ultra-fast Electrochemical Tool to Study Speciation of Trace Metals in Aqueous Solution

Trace metals play important roles in biological and ecological systems. In biology, trace metals act as catalytic or structural cofactors...

Real-time, Selective Detection of Copper(II) using Ionophore-grafted Carbon-fiber Microelectrodes

Rapid, selective detection of metals in complex samples remains an elusive goal that could provide critical analytical information for...

A Density-controlled Scaffolding Strategy for Covalent Functionalization of Carbon-fiber Microelectr

Trace metal detection is of great importance in environmental and biological systems. It is crucial to develop a portable and sensitive...

The Coaction of Tonic and Phasic Dopamine Dynamics

Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet...

Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transp

The distribution and density of neurons within the brain poses many challenges when making quantitative measurements of neurotransmission...

“Fast Voltammetry of Metals at Carbon-Fiber Microelectrodes: Copper Adsorption onto Activated Carbon

Rapid, in situ trace metal analysis is essential for understanding many biological and environmental processes. For example, trace metals...

Voltammetric and Mathematical Evidence for Dual Transport Mediation of Serotonin Clearance In Vivo

The neurotransmitter serotonin underlies many of the brain's functions. Understanding serotonin neurochemistry is important for improving...

Real-Time Subsecond Voltammetric Analysis of Pb in Aqueous Environmental Samples

Lead (Pb) pollution is an important environmental and public health concern. Rapid Pb transport during stormwater runoff significantly...

Fast-scan Cyclic Voltammetry Analysis of Dynamic Serotonin Responses to Acute Escitalopram

The treatment of depression with selective serotonin reuptake inhibitors, SSRIs, is important to study on a neurochemical level because...

Ultrafast Detection and Quantification of Brain Signaling Molecules with Carbon Fiber Microelectrode

Carbon fiber microelectrodes provide the ideal platform for performing ultrafast, selective measurements of electroactive brain...

Fast-Scan Deposition-Stripping Voltammetry at Carbon-Fiber Microelectrodes: Real-Time, Subsecond, Me

Elevated concentrations of hazardous metals in aquatic systems are known to threaten human health. Mobility, bioavailability, and...